APPENDIX 3. Kenya study abstract [Neurath 2005a]

s of papers accepted for XXVIth ISFR Conference Fluoride 2005;38(3):242-243 Abstract number: 32 XXVIth ISFR Conferencenumber: 32 XXVIth ISFR Conference APPENDIX 3. Kenya study abstract [Neurath 2005a] CN 12/11/2015 1 242 Abstracts of papers accepted for XXVIth ISFR Conference FLUORIDE THERAPY FOR OSTEOPOROSIS REVISITED Abstract number: Present in only trace amounts in soft tissues of the body, fluoride 31 normally accumulates to a significant extent with increasing age in XXVIth ISFR Conference metabolically active skeletal and dental tissues. With this fact in mind, elevated doses of fluoride (e.g., 50–60 mg NaF/day) have been advocated for treatment of post-menopausal and old-age onset osteoporosis, even though this condition is known to result not from lack of fluoride but mainly from long-term dietary deficiencies, inadequate physical activity, and hormonal imbalances. Although relief from pain associated with osteoporosis by fluoride therapy has been reported, and bone density is increased by such treatment, the resulting bone lacks tensile strength and is often more susceptible to fractures. Under certain circumstances fluoride can also promote arterial calcification leading to thromboses as first described by Rokitansky in 1842. Consequently, for these and other reasons, the use of fluorides for treatment of osteoporosis remains controversial scientifically.number: Present in only trace amounts in soft tissues of the body, fluoride 31 normally accumulates to a significant extent with increasing age in XXVIth ISFR Conference metabolically active skeletal and dental tissues. With this fact in mind, elevated doses of fluoride (e.g., 50–60 mg NaF/day) have been advocated for treatment of post-menopausal and old-age onset osteoporosis, even though this condition is known to result not from lack of fluoride but mainly from long-term dietary deficiencies, inadequate physical activity, and hormonal imbalances. Although relief from pain associated with osteoporosis by fluoride therapy has been reported, and bone density is increased by such treatment, the resulting bone lacks tensile strength and is often more susceptible to fractures. Under certain circumstances fluoride can also promote arterial calcification leading to thromboses as first described by Rokitansky in 1842. Consequently, for these and other reasons, the use of fluorides for treatment of osteoporosis remains controversial scientifically. Author: Mohamedally SM. Correspondence: 27 Woodside Gardens, Tottenham, London, UK N17 6UY. Email: [email protected]